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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

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The smell of food ‘wakes up’ the zebrafish visual system

New research from Leon Lagnado’s group in the LMB’s Neurobiology Division shows how food-related smells ‘re-tune’ zebrafish vision by making the retina more sensitive to moving objects, such as the prey that zebrafish eat.
The way the brain processes information from one sense depends on the activity of other senses. For instance, we all know that to listen closely to some music, it often helps to shut one’s eyes.

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Published on 11th July, 2013

Work on ubiquitination reveals insights into disease

Recent work carried out by David Komander’s group in the LMB’s Protein and Nucleic Acid Chemistry Division, and published in two separate papers, has provided insight into human disease and the role played by ubiquitination, a process that affects many fundamental cellular processes.
Work in David’s group aims to understand the cellular machinery for specific ubiquitin (Ub) assembly, disassembly, and binding on a structural and biochemical level.

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Published on 11th June, 2013

Insights into spliceosomal activation and molecular pathology of retinitis pigmentosa eye disease

Work published in the journal Structure by Kiyoshi Nagai’s group in the LMB’s Structural Studies Division, has provided further detailed information on the structure and role of proteins at the active site of the spliceosome, and may also help to explain the molecular pathology of the eye disease, retinitis pigmentosa type 13 (RP13).

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Published on 31st May, 2013

Watching neurons transmit visual information

Work in Leon Lagnado’s group in the LMB’s Neurobiology Division is showing how synapses transmit visual signals in the retina of zebrafish. The group designed fluorescent proteins that light up when synapses are active and made transgenic zebrafish expressing these proteins in retinal neurons. They then used a multiphoton microscope to directly observe the activity of synapses in the retina of live fish as they responded to different visual stimuli.

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Published on 21st May, 2013

New mechanism in the body’s timekeeping revealed

Our cycle of sleep and wakefulness is controlled by a daily (circadian) body clock in our brain. When this cycle happens in a regular way people function well, but when this cycle is disturbed it can lead to a severely disrupted life. The suprachiasmatic nucleus (SCN)  is part of the body clock and individual neurons of the SCN contain their own 24-hour clock, but they operate best when connected together in their neural circuit and run in synchrony.

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Published on 30th April, 2013

Understanding the mechanism of the nucleocytoplasmic transport cycle

New research, from a team of scientists in the LMB’s Structural Studies Division and the Texas A&M Health Science Center, illustrates the molecular mechanism behind a fundamental cellular process.
The research, published in PNAS, provides new insights into the way in which components of the nuclear protein transport machinery move through nuclear pores.

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Published on 29th April, 2013
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