MRC Laboratory of Molecular Biology
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.
One of the most commonly mutated genes in human cancers is the lipid kinase PIK3CA (phosphoinositide 3-kinase alpha). Mutations can activate this enzyme, resulting in proliferation of tumour cells and resistance to programmed cell death or apoptosis.
New research shows that acetaldehyde, the breakdown product generated when the body removes alcohol, causes irreversible damage to the DNA of stem cells in the body’s ‘blood cell factory’ – the bone marrow.
The research, published in Nature, was carried out by a team of scientists led by KJ Patel in the LMB’s PNAC Division.
In the past few years, the ability to incorporate unnatural amino acids into proteins has begun to have a direct impact on the ability of scientists to study biological processes that are difficult or impossible to address by more classical methods.
New research, led by members of Jason Chin’s group in the LMB’s PNAC Division, has for the first time focused on expanding the genetic code of a complex multicellular organism, the fruit fly Drosophila melanogaster.
New research, resulting from a collaboration between two groups, led by Sarah Teichmann and Madan Babu, in the LMB’s Structural Studies Division, advances our understanding of the interplay between the two most abundant classes of DNA binding proteins that are responsible for regulating physiological diversity in organisms.
A comprehensive investigation of several large-scale datasets, led by M. Madan Babu’s group in the LMB’s Structural Studies Division, provides new insights into tissue-specific splicing – the mechanism responsible for increasing the functional diversity of proteins and for attaining tissue identity during development.
New research, led by Philipp Holliger’s group in the LMB’s PNAC Division, has shed new light on the mechanism by which DNA polymerases – the enzymes responsible for replicating genomes in all animals, fungi and bacteria – are able to ensure faithful DNA replication while actively excluding damaged and/or non-cognate nucleotides from the genome.