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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Major breakthrough identifies cause and treatment of fatal autoimmune disease

Graphical depiction of symptoms of ORAS (OTULIN-related Autoinflammatory Syndrome)

The cause of a potentially fatal inherited autoimmune disease has been identified for the first time. The disease, now named OTULIN-related autoinflammatory syndrome (ORAS), was discovered by doctors treating patients who developed symptoms such as rashes, fever, and diarrhoea shortly after birth. The immune system of these patients spontaneously activates and starts to attack the patient’s own body leading to the described symptoms and eventually to the child’s death.

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Published on 12th August, 2016

Molecular basis of APC/C regulation by the spindle assembly checkpoint

During eukaryotic cell division (mitosis) the cell’s chromosomes are duplicated and then equally separated into two new daughter cells. To prevent errors in mitosis cells employ checkpoints that monitor and coordinate the correct order of events. Checkpoints either delay cell division, or if unrecoverable, cause cell death.

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Published on 11th August, 2016

HIV uses capsid pores to import nucleotides and evade innate immunity

HIV is a retrovirus, meaning it has to copy its RNA genome into DNA in order to infect cells. While much has been learned about the virus, investigators don’t understand how it evades our immune system so successfully. A long-standing question has been how the HIV virus copies its genome using raw materials from the cell without being detected by immune sensors.

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Published on 11th August, 2016

An evolutionarily conserved pathway controls proteasome homeostasis

Cell survival depends on adaptive signalling pathways to ensure that the supply of vital components matches the fluctuating needs of the cell. The proteasome is essential for the selective degradation of most cellular proteins and thereby controls virtually all cellular processes. The current prevailing view is that protein degradation is largely regulated at the level of ubiquitination.

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Published on 28th July, 2016

Structure of the catalytic spliceosome

model of spliceosome structure

The spliceosome is a molecular machine, which together with RNA polymerases and ribosomes plays a critical role in basic gene expression. Due to its highly dynamic nature the structure of the spliceosome has remained elusive until now. Research by Kiyoshi Nagai’s group, in the LMB’s Structural Studies Division, has for the first time captured the spliceosome in a fully active, substrate-bound state, immediately after first catalytic reaction.

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Published on 26th July, 2016

NBLAST – a new online tool to compare neurons

Researchers in Greg Jefferis’s group in the LMB’s Neurobiology Division have developed a new online tool to analyse images of neurons. This tool, known as NBLAST, is free and available to all. NBLAST enables researchers to measure the similarity between neurons and organise them into neuron families, akin to tools such as BLAST that allow protein sequences to be compared.
Neuroscience is seeing a period of major growth in the structural characterisation of neurons.

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Published on 20th July, 2016
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