• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

  • Home
  • About LMB
  • Research
  • Research Groups
  • Students
  • Recruitment
  • Life at the LMB
  • Achievements
  • News & Events
Home > News & Events > Insight on Research

Insight on Research

  • All
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010

TRIM21 senses infection and triggers immune response inside cells

New research, led by Leo James and Will McEwan from the LMB’s PNAC Division, has uncovered a previously unrecognised mechanism of intracellular pathogen detection which may provide a deeper understanding of how antibodies help fight disease and lead to the design of better vaccines and gene therapies.
Earlier research from Leo’s group showed that viruses carry antibodies into cells when they infect them [1].

More…

Published on 4th March, 2013

Uncovering molecular signatures of G-protein-coupled receptors

G-protein-coupled receptors (GPCRs) are a family of cell-surface proteins that are vital for various physiological functions including vision, smell, taste, and behavior. They are also the pharmacological targets of ~30% of prescribed drugs. For example, beta-blocker drugs prescribed for cardiac ailments target the β-adrenoreceptors − known GPCRs. The importance of GPCR biology was emphasised by the latest Nobel Prize in Chemistry (2012), awarded for studies of GPCRs.

More…

Published on 14th February, 2013

Ribosome structure determined to near-atomic resolution by cryo-EM

Determining the structure of proteins and other biomolecules at the atomic level is central to understanding many aspects of biology. X-ray crystallography is the best known technique for structural biology but, as its name suggests, it only works with samples that can be crystallized. Electron cryo-microscopy (cryo-EM) can be used to determine atomic structures of biomolecules that cannot be crystallized, but until now achieving high-resolution cryo-EM structures has been difficult.

More…

Published on 6th February, 2013

The guardian of the transcriptome

New research, from a team of scientists in the LMB’s Structural Studies Division and the EMBL-European Bioinformatics Institute, has uncovered how our genome keeps the effects of mutations in check. The discovery, published in the journal Cell, explains how new proteins are created, helping to deliver useful insights into the evolution of the human genome. The team’s findings may also help in improving our understanding of diseases such as cancer and neurodegeneration.

More…

Published on 1st February, 2013

Salt chemosensation in worms linked to human deafness

Transmembrane channel-like (TMC) genes encode a conserved family of predicted membrane proteins in animals. The founding member, human Tmc1, is strongly linked to deafness, being expressed in cochlear hair cells and known to be required for their function. However, the precise molecular function of these proteins has until now been unknown.

More…

Published on 31st January, 2013

Architecture of the spliceosome active site

Research in the group of Kiyoshi Nagai in the LMB’s Structural Studies Division has for the first time provided detailed information on the structure and role of proteins at the active site of the spliceosome, which is responsible for the excision of introns from messenger-RNA (mRNA) precursors in the nucleus.
The spliceosome is a large and dynamic RNA-protein assembly.

More…

Published on 24th January, 2013
  • «
  • ‹
  • 53
  • 54
  • 55
  • 56
  • 57
  • ›
  • »

Primary Sidebar

News & Events

  • Insight on Research
  • LMB News
  • LMB In The News
  • LMB Alumni News
  • Public Engagement
    • Supporting Education
      • I’m a scientist, get me out of here!
      • London International Youth Science Forum
    • LMB on the Road
      • Cambridge Festival
      • Royal Society Summer Science Exhibitions
      • Big Biology Day
      • LifeLab
    • Events at the LMB
      • Artists in Residence: Home in the Service of Science
      • LMB Open Day 2017
      • STEM in Song
    • Resources
      • Image Game
    • LMB Science Stories
      • Electron Cryo-microscopy
      • Tau and Alzheimer’s
    • Past Events
      • MRC Festival of Research
      • Crystal Growing Competition
        • Past Winners
        • MRC Lab Visits
      • The WormWatch Lab
    • Contact Us
  • Scientific Seminars
    • LMB Named Lectures
  • LMB Exhibitions
    • Sample holders for electron cryomicroscopy
    • Humira
    • Curios of 60 years of the LMB
  • Scientific Training
  • Information for Journalists
  • Scientific Glossary
  • Photographs
  • LMB 365
  • Newspaper Archive

Search

  • Privacy & Cookies
  • Contact Directory
  • Freedom of Information
  • Site Map
Find Us
©2025 MRC Laboratory of Molecular Biology,
Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. 01223 267000

The MRC is part of UK Research and Innovation

Contact Us

This site uses cookies. The LMB may use cookies to analyse how you use our website. We use external analysis systems which may set additional cookies to perform their analysis. These cookies (and any others in use) are detailed in our Privacy and Cookies Policy and are integral to our website. You can delete or disable these cookies in your web browser if you wish, but then our site may not work as it is designed. Ok