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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Insight on Research

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Link between shape shifting protein and HIV resistance

A group of collaborative researchers, led by Leo James’ group in the LMB’s PNAC Division, have discovered evidence that helps to explain why primates are more resistant to HIV than humans are.
Rhesus macaques are protected against HIV by a protein, Rhesus TRIMCyp (RhTC), which targets HIV inside cells thereby preventing infection. However, how RhTC targeted HIV viruses and why it remained effective, given the diversity of viral strains and their capacity for mutation, was unclear.

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Published on 12th March, 2012

Shedding light on cellular transport systems

For cells to perform their elaborate functions, various components must be delivered to the right place at the right time. This is dependent on the cellular equivalent of a railway system; tiny protein machines called molecular motor complexes transport cargoes to their destination by traversing a network of polarized tracks within the cell. However, it is not clear how transport is coordinated by the motor complexes and how different cargoes are delivered to different destinations.

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Published on 27th February, 2012

The sweet way of detecting bacterial invasion in cells

Felix Randow’s group in the LMB’s PNAC Division has identified Galectin-8 as a novel danger receptor and factor of the cellular machinery that protects human cells against bacterial invasion. Galectin 8, a sugar-binding protein in the cytosol, was discovered to be a key component in limiting the growth of Salmonella and to participate in the early line of defence against infection.

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Published on 16th January, 2012

Novel Mechanism for Regulating Inflammation and Cancer Discovered

Matthew Freeman’s group in the LMB’s Cell Biology Division have discovered a novel protein, iRhom2, that plays a central role in the signalling pathways that regulate inflammation and cancer.
The cytokine protein, TNF, is the primary trigger of inflammation in humans. To function, active TNF must be shed from cells by the protease TACE. TACE is also responsible for the cleavage of many important growth factors, that when deregulated can contribute to cancer.

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Published on 13th January, 2012

New evidence of nuocyte involvement in allergic asthma

Andrew McKenzie’s group in the LMB’s PNAC Division have shown for the first time that a new immune cell type, the nuocyte, can orchestrate the initiation of allergic asthma in an experimental model. Nuocytes were shown to cause airway hyperactivity – a key feature of human asthma.

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Published on 18th November, 2011

New intracellular transport system discovered.

Melina Schuh, in the LMB’s Cell Biology Division, has uncovered for the first time a new transport system for long-range transport of vesicles in animal cells. This discovery could re-write the textbooks on the subject.
Intracellular transport is vital for the function, survival and architecture of every cell. The contents of our body’s cells are constantly on the move.

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Published on 10th October, 2011
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