Insight on Research


Shedding light on how mRNA molecules navigate to their destination within the cell

Harish Chandra Soundararajan and Simon Bullock from the LMB’s Cell Biology Division have created a new technique for studying how dynein motors move individual mRNA molecules along microtubules, which has provided unique insights into cellular transport systems.
In order for a cell to function, its constituents have to be sorted to different locations. In many cases, this is achieved by an active intracellular transport system.

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Breakthrough in structural biology reveals mitochondrial ribosome structure

The bringing together of several independent lines of research by members of the LMB’s Structural Studies Division has led to the determination of the atomic structure of the yeast mitochondrial ribosome.  The work took advantage of recent developments in electron microscopy (EM), brought about by a decade of work at the LMB to develop better EM detectors.

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Coupling of transcription termination and mRNA processing

Work carried out by Lori Passmore’s group in the LMB’s Structural Studies Division, in collaboration with Patrick Cramer’s group in Munich, has revealed how transcription termination and mRNA processing by Cleavage and Polyadenylation Factor (CPF) are coupled via dephosphorylation of the C-terminal domain of RNA Polymerase II by CPF.
Genes code for proteins – the ‘doing-molecules’ in cells.

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