MRC Laboratory of Molecular Biology
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.
The latest advances in cryo-electron microscopy have enabled Sjors Scheres’ group, from the LMB’s Structural Studies Division, together with collaborators from Beijing in China, to solve the structure of human gamma-secretase, a membrane protein complex that has an important role in Alzheimer’s disease.
Gamma-secretase is made up of four different proteins which are all embedded within the cell membrane.
A cross divisional collaboration at the LMB between the groups of Simon Bullock, in Cell Biology, and Andrew Carter, in Structural Studies, has provided new insight into the activation of the large molecular motor dynein, a critical component of the transport system that operates within cells.
The cells within living organisms contain an elaborate transport system that moves different components to the right part of the cell at the right time.
A collaborative team from LMB’s Cell Biology and Structural Studies Divisions has visualized the mammalian protein synthesis and export machinery at near-atomic resolution. The new research helps explain how secreted proteins, such as hormones, can cross an otherwise impermeable membrane to exit the cell.
It has long been appreciated that cells communicate with each other via proteins that are either secreted or embedded in the cell’s surface.
During the development of an organism, whether it be a worm, fly, dog or human being, the early embryo must build different structures which will later become the body’s organs. Many structures within an organism are tubular: the veins and arteries; the gut; as well as the kidneys and lungs.
Research carried out by Eeson Rajendra from Lori Passmore’s group in the LMB’s Structural Studies Division, in close collaboration with KJ Patel from the LMB’s PNAC Division, has brought together LMB expertise in protein biochemistry and genetics to study the disease Fanconi Anaemia (FA). For the first time, they have isolated the intact FA core complex, and demonstrated which subunits are essential for monoubiquitination of FANCD2, which initiates the repair of damaged DNA in cells.
A collaboration between Roger Williams’ group here in the LMB’s Protein and Nucleic Acid Chemistry Division and Kevan Shokat’s group at the University of California, San Francisco has provided insight into potential targets for the design of a new class of anti-viral drugs.
Enteroviruses cause diseases including polio; hand, foot and mouth disease and the common cold, and there are currently no anti-viral treatments available to combat them.