Protein and Nucleic Acid Chemistry Division
The objectives of the Division are to gain insights into human biology and disease at the molecular level with a view to developing strategies for diagnosis and treatment.
Work in the Division focuses on biological processes central to immunity and cancer, and uses molecular, cellular and transgenic approaches, exploiting genomics, proteomics and molecular evolution.
In 2012 a new chemistry-oriented Centre for Chemical and Synthetic Biology (CCSB) was established, to help support the Division’s work in synthetic biology and strengthen its chemical expertise.
Joint Heads of Division:
Mariann Bienz and Michael Neuberger
Assistant Divisional Administrator:
Centre for Chemical and Synthetic Biology Administrator:
- Alexander Betz - The initiation of immune responses
- Mariann Bienz - Molecular mechanisms of Wnt signal transduction
- Jason Chin - Evolution and synthesis of new function
- Alan Fersht - Tumour suppressor p53 structure and drug discovery
- Michael Gait - Therapeutic oligonucleotides and their peptide conjugates
- Philipp Holliger - Synthetic biology of nucleic acid replication
- Leo James - Intracellular immunity
- David Komander - Specificity in the ubiquitin system
- Andrew McKenzie - Transgenic models of immune and haematopoietic disorders
- Michael Neuberger - Immunity and DNA deamination
- KJ Patel - Chromosome breakage and cancer predisposition
- Cristina Rada - Immunity and DNA deamination
- Felix Randow - Genetic analysis of signal transduction in innate immunity
- Julian Sale - Vertebrate mutagenesis and DNA damage tolerance
- John Sutherland - Chemical origins of molecular biology
- Roger Williams - Structural studies of phospholipid signalling