Structural Studies Division
The Division of Structural Studies seeks to understand the structure, function and interactions of biologically important molecules at the atomic, molecular and supramolecular level. The analytical methods employed include X-ray crystallography, NMR, electron microscopy and computational and theoretical studies, allied to biochemical and molecular biological approaches. Particular biological areas of focus include protein-nucleic acid complexes, molecules involved in cellular transport or motility, membrane proteins and structures associated with human disease. There is an increasing emphasis on analysis, interpretation and use of the wealth of data rapidly accruing from the multiple genome sequencing projects. There is a continuing development of computational techniques and instrumentation, where these are essential for scientific progress.
Other Divisions

Joint Heads of Division:
Venki Ramakrishnan and Jan Löwe
Divisional Administrator:
Jennie Lightfoot
Assistant Divisional Administrator:
Maud Pilkington
MRC Laboratory of Molecular Biology,
Francis Crick Avenue,
Cambridge Biomedical Campus,
Cambridge CB2 0QH,
UK.
Tel: +44 (0) 1223 267080
Fax: +44 (0) 1223 213556
Group Leaders
- M. Madan Babu - Systems biology
- Mark van Breugel - Structure and assembly mechanisms of centrioles
- Andrew Carter - The structure and mechanism of dynein
- Paula da Fonseca - Structure and function of cell regulatory protein complexes
- Richard Henderson - High resolution 3D structures by electron cryomicroscopy
- Meindert Lamers - DNA replication and translesion synthesis
- Andrew Leslie - Structural studies of macromolecules
- Jan Löwe - The bacterial cytoskeleton
- Garib Murshudov - Computational crystallography
- Alexey Murzin - Structural Classification of Proteins and its implications for the genome projects
- Kiyoshi Nagai - Crystallographic and biochemical studies of the spliceosome
- David Neuhaus - Solution structure by NMR spectroscopy
- Lori Passmore - Macromolecular machines involved in mRNA polyadenylation
- Venki Ramakrishnan - Structure of the translational apparatus
- Daniela Rhodes - Chromatin and telomere structure
- Sjors Scheres - Visualising molecular machines in action
- Murray Stewart - Molecular machinery of nuclear trafficking
- Chris Tate - Structural biology of integral membrane proteins
- Jernej Ule - Post-transcriptional regulatory networks
Emeritus Scientists
- Brad Amos - Optical microscope development
- Cyrus Chothia - The protein origins of biological complexity
- Tony Crowther - Structure of macromolecule assemblies
- Phil Evans - Structural studies of endocytosis components
- John Kendrick-Jones - Multi-functional myosin motors
- Aaron Klug - Engineering zinc finger proteins (ZFPs) for the regulation of gene expression