Molecular Immunity Unit
Menna Clatworthy
LMB Division – Molecular Immunity Unit
The Clatworthy lab is interested in understanding how B cell activation and IgG antibody effector function is regulated in different tissues, particularly in the kidney and the gut using cellular and molecular immunology, single cells RNA Sequencing and two-photon microscopy. More…
Tetsuo Hasegawa
LMB Division – Molecular Immunity Unit
Joint pain and inflammation are common manifestations of various systemic diseases. We are generating a 3D molecular atlas of the membrane in the joint, called synovium, to investigate why joints are responsive to diverse systemic pathologies, how communication between synovial cells and nociceptors influences disease progression, and what mechanisms underlie immune-driven pain in the joints. More…
Yorgo Modis
LMB Division – Molecular Immunity Unit
Viruses depend on host cell machinery to express and replicate their genes. Viral RNA must, therefore, be delivered or generated in the cytosol. Some viruses also deliver genomic DNA into the nucleus, where it can be integrated into the host cell genome. The cell’s principal innate antiviral defence is an inflammatory response that is activated upon sensing cytosolic viral RNA. More…
Lalita Ramakrishnan
LMB Division – Molecular Immunity Unit
We are interested in understanding the pathogenesis of tuberculosis and the basis of vastly different susceptibilities to this disease. Tuberculous infection results in the formation of granulomas, complex immune structures that are composed of differentiated macrophages, lymphocytes and other immune cells. However, bacteria can persist within granulomas despite the development of antigen-specific immunity. To understand the mechanistic basis of mycobacterial persistence, the mechanisms of granuloma formation and its role in tuberculosis, we have developed the zebrafish as a model to study immunity to tuberculosis. More…