My lab is interested in the generation of biological form or “morphogenesis”. While we have long studied morphogenesis in the context of developing tissues, our main focus has always been on events at the cellular scale. This is because the cell is the unit of life and because tissue movements are driven by changes in the shape and mechanical properties of individual cells, which in turn depend on forces generated by a small number of cytoskeletal elements within these cells.
The most extraordinary and fundamental of all morphogenetic processes is cell division: the process by which one cell becomes two. During division, in the space of a few minutes, all the component parts of the cell must be moved apart and partitioned into two daughter cells. Moreover, the process must be precise, since errors are associated with diseases like cancer in humans, and frequently cause cell death.
While our group, like many others, has long studied the cell biology of division in eukaryotic cells, it has recently become clear that many aspects of the process have been conserved over billions of years of evolution. In fact, many have their origins in archaea. To explore the fundamentals of the division process, my lab is therefore studying how both archaea and eukaryotic cells divide into two, using Sulfolobus (an archaeon), Drosophila, yeast and human cells as model systems. By doing so, we aim to identify the most deeply conserved processes and to discover how the division machinery changed during the evolution of eukaryotes. We also expect this work to shed light on the process by which the eukaryotic cell first emerged from the symbiosis of an archaeal cell and its bacterial partner – something that remains one of the greatest mysteries in the history of life on earth.
Finally, given the fundamental nature of cell division, we expect this work to improve our understanding of the way the core division machinery functions to aid normal tissue development and homeostasis and, when it goes awry, contributes to the evolution of metastatic cancer.
- J Liu, M Tassinari, D P Souza, S Naskar, JK Noel, O Bohuszewicz, M Buck, TA Williams, B Baum*, HH Low* (2020)
Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodelling superfamily.
- G Dey, S Culley, S Curran, U Schmidt, R Henriques, W Kukulski, and B Baum. (2020)
Closed mitosis requires local disassembly of the nuclear envelope.
Nature 585: 119-123.
- G Tarrason Risa, F Hurtig, S Bray, AE Hafner, L Harker-KirschnecK, P Faull, C Davis, D Papatziamou, DR Mutavchiev, C Fan, L Meneguello, AA Pulschen, G Dey, S Culley, M Kilkenny, L Pellegrini, RAM de Bruin, R Henriques, AP Snijders, A Šarić, A-C Lindås, NP Robinson* and B Baum* (2020)
The proteasome controls ESCRT-III-mediated cell division in an archaeon.
Science 369: (6504).
- AK Pfitzner, V Mercier, X Jiang, J Moser von Filseck, B Baum, A Šarić, A. Roux (2020)
Sequential polymerization of ESCRT subunits drives membrane deformation and fission
Cell 182: 1140-1155.
- DA Baum & B Baum (2020)
The merger that made us.
BMC Biol. 18(1): 72
- AA Pulschen, DR Mutavchiev, S Culley, KN Sebastian, J Roubinet, M Roubinet, G Tarrason Risa, M van Wolferen, C Roubinet, U Schmidt, G Dey, S-V Albers, R Henriques, B Baum. (2020)
Live Imaging of a Hyperthermophilic Archaeon Reveals Distinct Roles for Two ESCRT-III Homologs in Ensuring a Robust and Symmetric Division.
Current Biology 30: 1-8.
- Harker-Kirschneck L, Baum B, and Šarić, A. (2019)
Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico.
BMC Biol. 17: 82.
- HK Matthews, S Ganguli, K Plak, AV Taubenberger, M Piel, J Guck, B Baum. (2020)
Oncogenic signaling alters cell shape and mechanics to facilitate cell division under confinement.
Dev Cell 52(5): 563-573.
- Rodrigues, NT., Lekomtsev, S., Jananji, S., Kriston-Vizi, J., Hickson, GR., & Baum, B. (2015)
Kinetochore- localized PP1-Sds22 couples chromosome segregation to polar relaxation.
Nature 524(7566): 489-492.
- Baum, D, Baum, B. (2014)
An inside-out origin for eukaryote cells.
BMC Biol. 12: 76.
- Marinari, E., Mehonic, A., Curran, S., Gale, J., Duke, T., Baum, B. (2012)
Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding.
Nature 484(7395): 542-545.
- Oskar Batty
- Giulia Cazzagon
- Alice Cezanne
- Sherman Foo
- Baukje Hoogenberg
- Fredrik Hurtig
- Yin-Wei (Kris) Kuo
- Agata Nyga
- Joe Parham
- Diorge Paulo de Souza
- Chantal Roubinet
- Jovan Traparic