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MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

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Home > Research Leaders > N to S

N-to-S


Kelly Nguyen

Kelly Nguyen

LMB Division - Structural Studies

Molecular mechanism of telomere maintenance and the roles of telomeres in human diseases

Molecular mechanism of telomere maintenance and the roles of telomeres in human diseases More…

John O'Neill

LMB Division - Cell Biology

Cellular rhythms, signalling and metabolic regulation

Circadian (approximately daily) rhythms are cell-intrinsic phenomena that permeate every level of biology, and thereby impact upon many aspects of health and disease. More…

Lori Passmore

LMB Division - Structural Studies

Molecular Machines that regulate gene expression

Eukaryotic genes are normally transcribed as pre-mRNAs that must be processed before they are exported from the nucleus and translated into proteins. The pre-mRNA is cleaved and a poly(A) tail is added to its 3'end. More…

Venki Ramakrishnan

LMB Division - Structural Studies

Structure of the translational apparatus

Translation of genetic information into protein is fundamental to life. It is carried out by the large macromolecular machine called the ribosome. In 2000, we solved the structure of the 30S ribosomal subunit and its complex with several antibiotics as well as its mRNA and tRNA ligands. Since then, we have solved the high-resolution structures of the entire ribosome at several points along the translation pathway, leading to insights into decoding, translocation and termination. More…

Lalilta Ramakrishnan

Lalita Ramakrishnan

LMB Division - Cell Biology

Mechanisms of tuberculosis pathogenesis

TB remains a major cause of death despite a live attenuated vaccine (BCG) for a century and effective antibiotics for 60 years. TB’s persistence over millennia in the face of these major medical advances underscores the ability of Mycobacterium tuberculosis to evade and exploit host defenses and antibiotics. More…

Felix Randow

LMB Division - Protein and Nucleic Acid Chemistry

Cell-autonomous and innate immunity

We are interested in cell autonomous innate immunity, i.e. in the ability of individual cells to defend themselves against infection. More…

Jing Ren

Jing Ren

LMB Division - Neurobiology

Developmental assembly of the serotonin system

The serotonin (5HT) system is believed to be the most expansive neural system, innervating nearly every area of the brain and has been implicated in the modulation of seemingly every human behavior. It is the most frequently targeted neural system pharmacologically for treating psychiatric disorders, including depression and anxiety. More…

Christopher Russo

LMB Division - Structural Studies

Atomic resolution imaging of biological specimen by electron cryomicroscopy

Many of the outstanding questions in biology and medicine are difficult to address because there is no way to directly look at the complex molecular machines responsible for life. We work on developing new instruments and methods for imaging biological molecules, (DNA, RNA and proteins), at atomic resolution. More…

Benjamin Ryskeldi-Falcon

LMB Division - Neurobiology

Amyloids in neurodegenerative diseases

Ordered assembly of a small number of proteins within neurons and, in some cases, glia is a feature of neurodegenerative diseases. These proteins form amyloid structures enriched in repetitively stacked beta-strands. More…

Julian Sale

Julian Sale

LMB Division - Protein and Nucleic Acid Chemistry

Vertebrate mutagenesis and DNA damage tolerance

We wish to understand the mechanisms that alleviate replication arrest following DNA damage and their consequences for the formation of mutations, the driving force in the development of cancer. More…

Bill Schafer

William Schafer

LMB Division - Neurobiology

Cellular and molecular mechanisms of behaviour

Elucidating the mechanisms by which nervous systems process information and generate behaviour is among the fundamental problems of biology. Ultimately, it is desirable to understand these processes at the most basic level, that of molecules and cells. More…

Sjors Scheres

Sjors Scheres

LMB Division - Structural Studies

Visualising proteins in health and disease

We are intrigued by how proteins work. The genetic code determines the amino acid sequence of proteins, which in turn determines their 3D-structure. The precise 3D-arrangement of different types of atoms inside proteins allows them to perform the many types of functions that are needed to keep the cell alive. More…

Marta Shahbazi

Marta Shahbazi

LMB Division - Cell Biology

Pluripotency in embryogenesis and regeneration

Pluripotent stem cells have the unique capacity to generate all the cell types of the organism. In the embryo, they undergo concomitant changes in shape and identity to set the foundation of the body plan. More…

John Sutherland

John Sutherland

LMB Division - Protein and Nucleic Acid Chemistry

Chemical origins of molecular biology

A true understanding of biology must include knowledge of its chemical origins, and comprehending the chemical events that gave biology its foundations - cellular format, the central dogma, the genetic code - is therefore a fundamental aspect of natural science. More…

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Research Leaders

  • A to G
    • Matteo Allegretti
    • Radu Aricescu
    • David Barford
    • Buzz Baum
    • Anne Bertolotti
    • Tanmay Bharat
    • Mariann Bienz
    • Simon Bullock
    • Albert Cardona
    • Andrew Carter
    • Jason Chin
    • Gerry Crossan
    • Emmanuel Derivery
    • Michel Goedert
    • Julian Gough
    • Ingo Greger
  • H to M
    • Michael Hastings
    • Ramanujan Hegde
    • Richard Henderson
    • Philipp Holliger
    • Leo James
    • Gregory Jefferis
    • Patrycja Kozik
    • Madeline Lancaster
    • Jan Löwe
    • Kate McDole
    • Andrew McKenzie
    • Harvey McMahon
    • Liz Miller
    • Sean Munro
    • Garib Murshudov
  • N to S
    • Kelly Nguyen
    • John O’Neill
    • Lori Passmore
    • Lalita Ramakrishnan
    • Venki Ramakrishnan
    • Felix Randow
    • Jing Ren
    • Christopher Russo
    • Benjamin Ryskeldi-Falcon
    • Julian Sale
    • William Schafer
    • Sjors Scheres
    • Marta Shahbazi
    • John Sutherland
  • T to Z
    • Chris Tate
    • Marco Tripodi
    • Ana Tufegdžić Vidaković
    • Roger Williams
    • Joseph Yeeles
    • Suyang Zhang
    • Marta Zlatic
  • Emeritus
    • Brad Amos
    • Tony Crowther
    • Phil Evans
    • Alan Fersht
    • Michael Gait
    • Rob Kay
    • John Kendrick-Jones
    • John Kilmartin
    • Peter Lawrence
    • Andrew Leslie
    • David Neuhaus
    • Hugh Pelham
    • Daniela Rhodes
    • Murray Stewart
    • Andrew Travers
    • Nigel Unwin
    • Greg Winter
  • LMB Fellows
  • Molecular Immunity Unit

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