N to S

Kiyoshi Nagai
LMB Division - Structural Studies
CryoEM, crystallographic and biochemical studies of the spliceosome

The excision of introns from mRNA precursors is catalysed by the large and dynamic RNA-protein assembly called the spliceosome. Four large RNA-protein complexes, termed U1, U2, U5 and U4/ U6 snRNPs, and numerous non-snRNP proteins assemble on mRNA precursors and are remodelled extensively to form the catalytically active spliceosome. More…

David Neuhaus
LMB Division - Structural Studies
Solution structure by NMR spectroscopy

Nuclear magnetic resonance (NMR) spectroscopy is the most powerful physical method available for the study of molecular structure in the solution state, probing interactions between nuclei to reveal their spatial relationships and dynamic properties. More…

John O'Neill
LMB Division - Cell Biology
Cellular rhythms, signalling and metabolic regulation

Circadian (approximately daily) rhythms are cell-intrinsic phenomena that permeate every level of biology, and thereby impact upon many aspects of health and disease. More…

Lori Passmore
LMB Division - Structural Studies
Molecular machines that regulate mRNA polyA tails

Eukaryotic genes are normally transcribed as pre-mRNAs that must be processed before they are exported from the nucleus and translated into proteins. The pre-mRNA is cleaved and a poly(A) tail is added to its 3'end. More…

KJ Patel
LMB Division - Protein and Nucleic Acid Chemistry
Chromosome breakage and repair in stem cells

We study endogenous DNA damage and its impact on the function of vertebrate stem cells and the ageing process. Our recent work has shown that metabolism releases reactive aldehydes that are a potent source of such endogenous DNA damage. More…

Hugh Pelham
LMB Division - Cell Biology
Membrane protein sorting

Eukaryotic cells are subdivided into membrane-bounded organelles, each with a characteristic set of membrane proteins. These proteins must be targeted to their correct locations, a process which involves segregation of membrane proteins into small vesicles which bud from one compartment and fuse with another More…

Venki Ramakrishnan
LMB Division - Structural Studies
Structure of the translational apparatus

Translation of genetic information into protein is fundamental to life. It is carried out by the large macromolecular machine called the ribosome. In 2000, we solved the structure of the 30S ribosomal subunit and its complex with several antibiotics as well as its mRNA and tRNA ligands. Since then, we have solved the high-resolution structures of the entire ribosome at several points along the translation pathway, leading to insights into decoding, translocation and termination. More…

Felix Randow
LMB Division - Protein and Nucleic Acid Chemistry
Cell-autonomous and innate immunity

We are interested in cell autonomous innate immunity, i.e. in the ability of individual cells to defend themselves against infection. More…

Katja Röper
LMB Division - Cell Biology
Regulation of cell shape by the cytoskeleton during tissue morphogenesis

Epithelia constitute one of the major tissue types in all animals and form the basic building blocks of tubular organs in both vertebrates and invertebrates. Simple epithelial sheets are also the basic starting point in the development of most animals. We want to dissect how simple epithelial sheets deform in a highly concerted manner to turn into complex tubular tissue shapes. More…

Christopher Russo
LMB Division - Structural Studies
Atomic resolution imaging of biological specimen by electron cryomicroscopy

Many of the outstanding questions in biology and medicine are difficult to address because there is no way to directly look at the complex molecular machines responsible for life. We work on developing new instruments and methods for imaging biological molecules, (DNA, RNA and proteins), at atomic resolution. More…

Julian Sale
LMB Division - Protein and Nucleic Acid Chemistry
Vertebrate mutagenesis and DNA damage tolerance

We wish to understand the mechanisms that alleviate replication arrest following DNA damage and their consequences for the formation of mutations, the driving force in the development of cancer. More…

William Schafer
LMB Division - Neurobiology
Cellular and molecular mechanisms of behaviour

Elucidating the mechanisms by which nervous systems process information and generate behaviour is among the fundamental problems of biology. Ultimately, it is desirable to understand these processes at the most basic level, that of molecules and cells. More…

Sjors Scheres
Sjors Scheres
LMB Division - Structural Studies
Visualising molecular machines in action

Molecular machines are large and flexible macromolecular assemblies that fulfill a wide range of vital processes in the cell. Understanding how these machines work is a strategic goal in modern molecular biology. More…

John Sutherland
LMB Division - Protein and Nucleic Acid Chemistry
Chemical origins of molecular biology

A true understanding of biology must include knowledge of its chemical origins, and comprehending the chemical events that gave biology its foundations - cellular format, the central dogma, the genetic code - is therefore a fundamental aspect of natural science. More…