• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
MRC Laboratory of Molecular Biology

MRC Laboratory of Molecular Biology

One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health.

  • Home
  • About LMB
  • Research
  • Research Groups
  • Students
  • Recruitment
  • Life at the LMB
  • Achievements
  • News & Events
Home > Research Leaders > Emeritus > Peter Lawrence
cb

Peter Lawrence

Pattern formation in development


Personal group site

Peter Lawrence did his Ph.D. (1962-65) with the great insect physiologist VB Wigglesworth. He selected a large problem and has so far worked on it for 50 years: how are animals designed and built?

In 1969 Brenner and Crick invited him to the LMB to their new Cell Biology division. Lawrence has made many contributions to developmental biology; he was a pioneer in analysing how morphogen gradients drive both pattern and polarity, is a joint discoverer of compartments in development and (with Morata) found evidence that homeotic genes build a binary genetic address used to specify the developmental fate of precisely defined groups of embryonic cells.

He believes that genetics is the “master science of biology” (Brenner) and has used genetic mosaics to illuminate how a complex animal is put together. Since his retirement from the LMB in 2006, he has worked in the Zoology Department, Cambridge, supported by that Department, by the Wellcome Trust and by the LMB. He is an outspoken critic of many aspects of modern science. He believes that the LMB was an experiment that worked brilliantly and that this past success provides arguments to resist the current fashions and policies in scientific practice.


We are continuing to work on animal design and pattern formation in Drosophila, particularly studying planar cell polarity (PCP) with both molecular and genetic techniques. We collaborate with Gary Struhl (Columbia, NY), David Strutt and colleagues (Sheffield) and JP Vincent and colleagues (MRC, Crick Institute).

We have made discoveries that have changed the field of PCP. For example, we have found that the Flamingo (aka Stan) is a key molecule: e?xchange of polarity information occurs via homodimers of Flamingo that form bridges from cell to cell. There are two genetic systems responsible for PCP, the Stan system and the Dachsous system and we have found that these act independently.

Any applicants to join my group should apply to me care of:

Department of Zoology
University of Cambridge,
Downing St, Cambridge CB2 3EJ

where we are located.

Telephone : +44 (0)1223 769015
Email :

Selected Papers

  • Rovira, M., Saavedra, P., Casal, J. and Lawrence, P.A (2015)
    Regions within a single epidermal cell of Drosophila can be planar polarised independently
    eLife 4: e06303
  • Lawrence, P.A., Struhl, G. and Casal, J. (2007)
    Planar cell polarity: one or two pathways?
    Nature Reviews Genetics 8: 555-563
  • Lawrence, P.A. (1992)
    The Making of a Fly.
    Blackwell Scientific Publications, Oxford, pp 240

Primary Sidebar

Research Leaders

  • A to G
    • Matteo Allegretti
    • Radu Aricescu
    • David Barford
    • Buzz Baum
    • Anne Bertolotti
    • Tanmay Bharat
    • Mariann Bienz
    • Simon Bullock
    • Albert Cardona
    • Andrew Carter
    • Jason Chin
    • Gerry Crossan
    • Emmanuel Derivery
    • Michel Goedert
    • Julian Gough
    • Ingo Greger
  • H to M
    • Michael Hastings
    • Ramanujan Hegde
    • Richard Henderson
    • Philipp Holliger
    • Leo James
    • Gregory Jefferis
    • Patrycja Kozik
    • Madeline Lancaster
    • Jan Löwe
    • Kate McDole
    • Andrew McKenzie
    • Harvey McMahon
    • Liz Miller
    • Sean Munro
    • Garib Murshudov
  • N to S
    • Kelly Nguyen
    • John O’Neill
    • Lori Passmore
    • Lalita Ramakrishnan
    • Venki Ramakrishnan
    • Felix Randow
    • Jing Ren
    • Christopher Russo
    • Benjamin Ryskeldi-Falcon
    • Julian Sale
    • William Schafer
    • Sjors Scheres
    • Marta Shahbazi
    • John Sutherland
  • T to Z
    • Chris Tate
    • Marco Tripodi
    • Ana Tufegdžić Vidaković
    • Roger Williams
    • Joseph Yeeles
    • Suyang Zhang
    • Marta Zlatic
  • Emeritus
    • Brad Amos
    • Tony Crowther
    • Phil Evans
    • Alan Fersht
    • Michael Gait
    • Rob Kay
    • John Kendrick-Jones
    • John Kilmartin
    • Peter Lawrence
    • Andrew Leslie
    • David Neuhaus
    • Hugh Pelham
    • Daniela Rhodes
    • Murray Stewart
    • Andrew Travers
    • Nigel Unwin
    • Greg Winter
  • LMB Fellows
  • Molecular Immunity Unit

Search

  • Privacy & Cookies
  • Contact Directory
  • Freedom of Information
  • Site Map
Find Us
©2023 MRC Laboratory of Molecular Biology,
Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. 01223 267000

The MRC is part of UK Research and Innovation

Contact Us