H to M

Michael Hastings
LMB Division - Neurobiology
Molecular neurobiology of circadian timing

Circadian rhythms are those daily cycles of physiology and behaviour that persist when organisms are isolated from the external world. They are expressed at all levels of life, from prokaryotic blue-green algae to higher plants and animals. More…

Ramanujan Hegde
LMB Division - Cell Biology
Membrane protein biosynthesis and quality control

Cells are highly compartmentalized into numerous membrane-bound organelles. The membranes that define each organelle contain unique sets of embedded proteins that impart distinct functionalities to that organelle. How are all these different proteins selectively targeted to their correct destinations? And once they get there, how are membrane proteins inserted, folded, and assembled properly into the lipid bilayer? More…

Richard Henderson
LMB Division - Structural Studies
High resolution 3D structures by electron cryomicroscopy

We aim to determine the atomic structure of interesting or important membrane proteins and membrane protein complexes. Although much can be done using existing methods such as X-ray crystallography of 3D crystals or electron crystallography of 2D crystals, there are still many structures that have resisted our best efforts to crystallise them. More…

Philipp Holliger
LMB Division - Protein and Nucleic Acid Chemistry
Synthetic biology of nucleic acid replication

A critical event in the origin of life is thought to be the emergence of a molecule capable of self-replication as well as mutation, and hence evolution towards more efficient replication. We have built a powerful in vitro system for directed evolution, called compartmentalized self-replication (CSR), which mimics this process in the laboratory. More…

Leo James
LMB Division - Protein and Nucleic Acid Chemistry
Intracellular immunity

Despite extracellular adaptive and innate immunity, viral and bacterial pathogens are still able to infect cells. Because of this there must be a way to neutralise pathogens once they are inside the cell. Historically, infected cells have been seen as largely helpless and only able to signal for help. More…

Greg Jefferis
Gregory Jefferis
LMB Division - Neurobiology
Olfactory perception in the fruit fly

Our broad goal is to understand how smell turns into behaviour in the fruit fly brain. We currently use a combination of genetic labelling and manipulation, targeted in vivo whole cell patch clamp recording and high resolution computational neuroanatomy to study olfactory circuits. More…

Patrycja Kozik
LMB Division - Protein and Nucleic Acid Chemistry
Dendritic cells and initiation of the immune responses

Dendritic cells play a key role in initiation of cytotoxic immune responses against pathogens and tumours. In order to prime the relevant T cells, they acquire antigens from infected or cancer cells and process them for presentation on MHC class I molecules. More…

Wanda Kukulski
LMB Division - Cell Biology
Understanding membrane function, dynamics and architecture

Eukaryotic cells use membranes to organize their numerous intracellular processes. These membranes are not just inert barriers. They are compositionally and morphologically dynamic, and their shape and topology are intimately tied to organelle function. More…

Madeline Lancaster
LMB Division - Cell Biology
Human brain development in cerebral organoids

Human brain development in cerebral organoids More…

Jan Löwe
LMB Division - Structural Studies
The bacterial cytoskeleton

Many cellular processes depend on complex proteins that share characteristics with machines: they contain multiple components, and make use of mechanical devices such as lever arms. More…

Andrew McKenzie
LMB Division - Protein and Nucleic Acid Chemistry
Transgenic models of immune and haematopoietic disorders

Immune cells secrete a spectrum of interleukins, which play a critical role in regulating antibody production, inflammation and haematopoiesis. Dysregulation of these factors can lead to the manifestation of diseases such as asthma, autoimmunity and leukaemia More…

Harvey McMahon
LMB Division - Neurobiology
Membrane curvature as an organizing principle for eukaryotic cell biology

Cell shape is adapted to function. Organelle shape and local membrane architectures are likewise optimised for the processes that take place on and within these microenvironments. More…

Liz Miller
Liz Miller
LMB Division - Cell Biology
Protein transport and quality control in the secretory pathway

Cells efficiently assemble and transport a complex repertoire of proteins that reside within the membranes of the secretory pathway. This biogenesis pathway is subject to quality control such that only accurately assembled proteins are selected for forward traffic. We aim to understand the basic mechanisms that regulate secretion in the context of protein folding. More…

Sean Munro
LMB Division - Cell Biology
Small G proteins and the organisation of the Golgi apparatus

The compartments of the secretory and endocytic pathways are connected by membrane-bound carriers that bud from, and then fuse with, specific organelles. The accuracy of this traffic depends on the organelles having an 'identity' by which the trafficking machinery can recognise them. More…

Garib Murshudov
LMB Division - Structural Studies
Computational structural biology

Proteins, nucleic acids and other biological macromolecules take part virtually in all processes within living organisms. Knowledge of their 3-dimensional structures is essential for understanding how they work. X-ray crystallography is a powerful experimental technique that gives 3D structures with high accuracy. More…