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MRC Laboratory of Molecular Biology

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Home > Research Leaders > A to G

A-to-G


Matteo Allegretti

Matteo Allegretti

LMB Division - Structural Studies

The macromolecular basis of compartment remodelling

The cell is the simplest living metabolic entity. Organelles are cellular compartments specialized in a certain function. The nucleus is the essential cell compartment containing the genetic information. Our research aims to understand the molecular basis of how the nucleus is remodelled in shape during differentiation processes or due to environmental cues. More…

Radu Aricescu

LMB Division - Neurobiology

The structural biology of synaptic connectivity

Neuronal circuits are the biological substrates for all aspects of brain function such as learning, memory, thought, speech or consciousness. The synapses, connecting points between neurons, are continuously remodelled in response to novel experiences and hold the key to understanding how these circuits work. More…

David Barford

LMB Division - Structural Studies

Mechanism and regulation of chromosome segregation in mitosis

The anaphase-promoting complex (APC/C) is a large multi-subunit complex (~1.2 MDa) that functions to regulate cell cycle transitions, specifically the metaphase to anaphase transition in mitosis (when duplicated sister chromatid pairs are separated), the exit from mitosis and maintenance of G1. More…

Benjamin (Buzz) Baum

Buzz Baum

LMB Division - Cell Biology

The generation and evolution of biological form

My lab is interested in the generation of biological form or “morphogenesis”. While we have long studied morphogenesis in the context of developing tissues, our main focus has always been on events at the cellular scale. More…

Anne Bertolotti

Anne Bertolotti

LMB Division - Neurobiology

Understanding and preventing the deposition of misfolded proteins

Deposition of proteins of aberrant conformation is the hallmark of several neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and prion disorders. Cells have elaborate quality control mechanisms to protect them from the deleterious effect of misfolded proteins. More…

Tanay Bharat

Tanmay Bharat

LMB Division - Structural Studies

Electron tomography of prokaryotic cell surfaces

Our laboratory uses electron tomography, combined with several structural and cell biology techniques, to study cell surfaces of prokaryotes at the atomic level. More…

mariann-bienz

Mariann Bienz

LMB Division - Protein and Nucleic Acid Chemistry

Molecular mechanisms of Wnt signal transduction

The Wnt signalling pathway controls animal development and tissue homeostasis, and is also a major cancer pathway. Its key effector is β-catenin, which is stabilized in response to Wnt stimulation; it thus binds to TCF factors in the nucleus, and functions as a co-activator to mediate Wnt-induced transcription. Inappropriate activation of β-catenin can cause cancer in many human tissues, most notably colorectal cancer. More…

Simon Bullock

LMB Division - Cell Biology

Molecular cell biology of cytoskeletal transport

Molecular motors have critical roles in trafficking of organelles and macromolecules within the cytoplasm, and aberrant motor function has been implicated in diseases such as neurodegeneration. More…

Albert Cardona

Albert Cardona

LMB Division - Neurobiology

Experimental and comparative connectomics

The brain works as an integrated whole. Animals interact with the world by combining inputs from their senses of vision, hearing, smell, taste, touch and multiple others, with memories of past experiences, to then select a single, appropriate motor response that we observe as behavior. More…

Andrew Carter

Andrew Carter

LMB Division - Structural Studies

The structure and mechanism of dynein

The contents of eukaryotic cells are organised and moved around by motor proteins running along the tracks that make up the cytoskeleton (microtubules and actin filaments). The largest and most complicated of these is the microtubule motor cytoplasmic dynein. More…

Jason Chin

LMB Division - Protein and Nucleic Acid Chemistry

Systematic genetic code reprogramming / Centre for Chemical and Synthetic Biology

Biomolecules and their dynamic assemblies, in collaboration with the energy provided by NTP hydrolysis, perform a spectacular range of mechanical and chemical manipulations on nanometre scale objects in the cell; molecular motors perform mechanical work, while enzymes rearrange atoms in ways, and at rates that synthetic chemists have difficulty emulating. More…

Gerry Crossan

LMB Division - Protein and Nucleic Acid Chemistry

Maintenance of genome stability in the germline

The repair of damaged DNA is essential in all cells to ensure that the fidelity of the genome is maintained and to prevent mutations arising. This is of particular importance in stem cells, as mutations will not only effect that individual cell but the many millions of progeny derived from it. More…

Emmanuel Derivery

LMB Division - Cell Biology

Mechanisms of polarized trafficking induced by cytoskeleton asymmetries

Our goal is to establish the molecular mechanisms that generate cytoskeletal asymmetries during asymmetric cell division and to determine how, in turn, these cytoskeletal asymmetries generate polarized trafficking/signaling during development. More…

Michel Goedert

LMB Division - Neurobiology

Molecular mechanisms of neurodegeneration

Alzheimer’s disease and Parkinson’s disease are characterized by the presence of abnormal filamentous assemblies within some nerve cells. Similar assemblies are found in several related disorders. The events leading to filament formation or the mere presence of filaments are believed to produce nerve cell degeneration. More…

Julian Gough

Julian Gough

LMB Division - Structural Studies

Computational genomics

Medical research, and the molecular biology that it relies on, can be advanced in many ways using theoretical and computational approaches, mostly by harnessing the power of small and big data generated by experimental methods. More…

Ingo Greger

Ingo Greger

LMB Division - Neurobiology

AMPA receptor biogenesis, structure and function

Information transfer in the nervous system occurs at synapses where presynaptic signals are interpreted by postsynaptic receptors. We study this process with a focus on AMPA-type glutamate receptors, at various levels of complexity. More…

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Research Leaders

  • A to G
    • Matteo Allegretti
    • Radu Aricescu
    • David Barford
    • Buzz Baum
    • Anne Bertolotti
    • Tanmay Bharat
    • Mariann Bienz
    • Simon Bullock
    • Albert Cardona
    • Andrew Carter
    • Jason Chin
    • Gerry Crossan
    • Emmanuel Derivery
    • Michel Goedert
    • Julian Gough
    • Ingo Greger
  • H to M
    • Michael Hastings
    • Ramanujan Hegde
    • Richard Henderson
    • Philipp Holliger
    • Leo James
    • Gregory Jefferis
    • Patrycja Kozik
    • Madeline Lancaster
    • Jan Löwe
    • Kate McDole
    • Andrew McKenzie
    • Harvey McMahon
    • Liz Miller
    • Sean Munro
    • Garib Murshudov
  • N to S
    • Kelly Nguyen
    • John O’Neill
    • Lori Passmore
    • Lalita Ramakrishnan
    • Venki Ramakrishnan
    • Felix Randow
    • Jing Ren
    • Christopher Russo
    • Benjamin Ryskeldi-Falcon
    • Julian Sale
    • William Schafer
    • Sjors Scheres
    • Marta Shahbazi
    • John Sutherland
  • T to Z
    • Chris Tate
    • Marco Tripodi
    • Ana Tufegdžić Vidaković
    • Roger Williams
    • Joseph Yeeles
    • Suyang Zhang
    • Marta Zlatic
  • Emeritus
    • Brad Amos
    • Tony Crowther
    • Phil Evans
    • Alan Fersht
    • Michael Gait
    • Rob Kay
    • John Kendrick-Jones
    • John Kilmartin
    • Peter Lawrence
    • Andrew Leslie
    • David Neuhaus
    • Hugh Pelham
    • Daniela Rhodes
    • Murray Stewart
    • Andrew Travers
    • Nigel Unwin
    • Greg Winter
  • LMB Fellows
  • Molecular Immunity Unit

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