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Neuronal circuits are the biological substrates for all aspects of brain function such as learning, memory, thought, speech or consciousness. The synapses, connecting points between neurons, are continuously remodelled in response to novel experiences and hold the key to understanding how these circuits work. More…

The molecules of life, such as proteins, nucleic acids and metabolites, have traditionally been studied in isolation. It is becoming increasingly clear that they are tied together to form a large, inter-linked, complex system that is highly regulated at multiple levels of organization. More…

The anaphase-promoting complex (APC/C) is a large multi-subunit complex (~1.2 MDa) that functions to regulate cell cycle transitions, specifically the metaphase to anaphase transition in mitosis (when duplicated sister chromatid pairs are separated), the exit from mitosis and maintenance of G1. More…

Deposition of proteins of aberrant conformation is the hallmark of several neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and prion disorders. Cells have elaborate quality control mechanisms to protect them from the deleterious effect of misfolded proteins. More…

The Wnt signalling pathway controls animal development and tissue homeostasis, and is also a major cancer pathway. Its key effector is β-catenin, which is stabilized in response to Wnt stimulation; it thus binds to TCF factors in the nucleus, and functions as a co-activator to mediate Wnt-induced transcription. Inappropriate activation of β-catenin can cause cancer in many human tissues, most notably colorectal cancer. More…

Centrioles are large and complex cell organelles that form the core of centrosomes and are essential for templating cilia and flagella. These structures are important for many cellular functions like cell division, fluid movement, motility, and sensing. Thus, it is not surprising that centriole dysfunction is associated with many human diseases like microcephaly, ciliopathies and probably cancer and infertility. More…

We study the structure and the molecular assembly mechanisms of important, pathogenic, enveloped viruses (e.g. HIV and Influenza virus), and of cellular trafficking vesicles (e.g. clathrin and COPI coated vesicles). More…

Molecular motors have critical roles in trafficking of organelles and macromolecules within the cytoplasm, and aberrant motor function has been implicated in diseases such as neurodegeneration. More…

The contents of eukaryotic cells are organised and moved around by motor proteins running along the tracks that make up the cytoskeleton (microtubules and actin filaments). The largest and most complicated of these is the microtubule motor cytoplasmic dynein. More…

Biomolecules and their dynamic assemblies, in collaboration with the energy provided by NTP hydrolysis, perform a spectacular range of mechanical and chemical manipulations on nanometre scale objects in the cell; molecular motors perform mechanical work, while enzymes rearrange atoms in ways, and at rates that synthetic chemists have difficulty emulating. More…

The repair of damaged DNA is essential in all cells to ensure that the fidelity of the genome is maintained and to prevent mutations arising. This is of particular importance in stem cells, as mutations will not only effect that individual cell but the many millions of progeny derived from it. More…

Brains are highly parallel information processors. Their neural circuits continuously integrate sensory inputs to generate appropriate behavioural responses. More…

Our goal is to establish the molecular mechanisms that generate cytoskeletal asymmetries during asymmetric cell division and to determine how, in turn, these cytoskeletal asymmetries generate polarized trafficking/signaling during development. More…

In all living cells homeostasis, growth and division are critically regulated by highly specialised large multi-subunit protein complexes. Disruptions in these regulatory complexes result in cell malfunctioning and are frequently implicated in diseases such as cancer. More…

The ‘wiring’ of neuronal circuits in the mammalian brain is mediated by synapses, which are responsible for processing and storing information. We are interested in understanding the native molecular architecture of synapses with a particular focus on postsynaptic membranes that contain N-methyl D-aspartic acid receptors (NMDARs). More…

Alzheimer’s disease and Parkinson’s disease are characterized by the presence of abnormal filamentous assemblies within some nerve cells. Similar assemblies are found in several related disorders. The events leading to filament formation or the mere presence of filaments are believed to produce nerve cell degeneration. More…

Medical research, and the molecular biology that it relies on, can be advanced in many ways using theoretical and computational approaches, mostly by harnessing the power of small and big data generated by experimental methods. More…

Information transfer in the nervous system occurs at synapses where presynaptic signals are interpreted by postsynaptic receptors. We study this process with a focus on AMPA-type glutamate receptors, at various levels of complexity. More…