T-to-Z
Chris Tate
LMB Division - Structural Studies
Structure and function of G protein-coupled receptors
Integral membrane proteins are fundamental to a cell's survival, allowing the import of nutrients, the export of toxins and intercellular communication via receptors. We aim to understand the processes of solute translocation and receptor signalling processes by determining the structures of important and interesting membrane proteins by x-ray crystallography. More…
Marco Tripodi
LMB Division - Neurobiology
Neural circuits for goal-oriented actions
One of the major tasks that the nervous system faces is that of linking perception to action. We perceive the world around us through our senses and we use this information to select the most appropriate set of actions. More…
Ana Tufegdžić Vidaković
LMB Division - Protein and Nucleic Acid Chemistry
Molecular basis of gene transcription
Gene transcription is an essential cellular process. Yet, RNA polymerase II (RNAPII) is constantly faced with challenges on its way across the gene. One of the main roadblocks to transcription are different types of DNA damage, which cause RNAPII stalling and prevent forward transcription. More…
Roger Williams
LMB Division - Protein and Nucleic Acid Chemistry
Structural studies of phosphoinositide signalling and intracellular sorting
Most receptor-mediated signal transduction pathways in mammalian cells involve enzymes that generate either soluble or membrane-resident second messengers by modifying phospholipids present in cell membranes. More…
Joseph Yeeles
LMB Division - Protein and Nucleic Acid Chemistry
Mechanisms of chromosome replication
Precise chromosome replication is essential for maintaining genome stability, yet the process itself is inherently risky. Duplex DNA must be transiently separated into unstable single-strands; a vast number of DNA bases must be accurately copied; and replication forks frequently encounter protein barriers and unrepaired DNA damage. More…
Suyang Zhang
LMB Division - Structural Studies
Mechanism of transcription-coupled alternative splicing
Splicing of precursor messenger RNA (pre-mRNA) is a ubiquitous hallmark of gene expression in all eukaryotes. Within the cell, splicing occurs simultaneously with pre-mRNA synthesis by RNA polymerase II (Pol II) and is mechanistically coupled to transcription. More…
Marta Zlatic
LMB Division - Neurobiology
Circuit mechanisms of learning and action-selection
The Zlatic lab aims to understand the relationship between the structure of the nervous system and its function and to discover the basic principles by which neural circuits implement fundamental computations. More…
Jerome Zurcher
LMB Division - Protein and Nucleic Acid Chemistry
Genome Synthesis and Genetic Isolation
The Zürcher lab develops methods for the synthesis of entire genomes and applies them for the genetic isolation of organisms. More…