Zibaee, S., Fraser, G., Jakes, R., Owen, D., Serpell, L.C., Crowther, R.A. & Goedert, M. (2010)
Human β-synuclein rendered fibrillogenic by designed mutations.
J. Biol. Chem. 285, 38555-38567.
Coomaraswamy, J., Kilger, E., Wölfing, H., Schäfer, C., Kaeser, S.A., Wegenast-Braun, B., Hefendehl, J.K., Wolburg, H., Mazzella, M., Ghiso, J., Goedert, M., Akiyama, H., Garcia-Sierra, F., Wolfer, D.P., Mathews, P.M. & Jucker, M. (2010)
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.
Proc. Natl. Acad. Sci. (USA) 107, 7969-7974.
Clavaguera, F., Bolmont, T., Crowther, R.A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A.K., Beibel, M., Staufenbiel, M., Jucker, M., Goedert, M. & Tolnay, M. (2009)
Transmission and spreading of tauopathy in transgenic mouse brain.
Nat. Cell Biol. 11, 909-913.
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Group Members
- Isabelle Lavenir
- Sarah Lummis
- John O'Brien
- Hirotaka Yoshida
- Graham Fraser
- Iraad Bronner
- Jennifer Macdonald
- René Frank
- Shahin Zibaee
- Ben Falcon
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Alzheimer's disease and Parkinson's disease are characterized by the presence of abnormal filamentous assemblies within some nerve cells. Similar assemblies are found in several related disorders. The events leading to filament formation or the mere presence of filaments are believed to produce nerve cell degeneration.
Our work has shown that the intraneuronal filaments found in these diseases are made of either microtubule-associated protein tau or α-synuclein.
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Group Leaders 
