MRC Laboratory of Molecular Biology

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Home Group Leaders H to M Gregory Jefferis
Gregory Jefferis

Olfactory perception in the fruit fly

Grosjean Y, Rytz R, Farine JP, Abuin L, Cortot J, Jefferis GS, Benton R. (2011).
An olfactory receptor for food-derived odours promotes male courtship in Drosophila.
Nature. 478, 236-40.

Cachero, S., Ostrovsky, A., Yu, J., Dickson, B., Jefferis, G. (2010).
Sexual Dimorphism in the Fly Brain.
Current Biology Vol 20 18, 1589-1601.

Jefferis, G.S.X.E., Potter, C.J., Chan, A.M., Marin, E.C., Rohlfing, T., Maurer Jr., C.R. & Luo, L. (2007).
Comprehensive maps of Drosophila higher olfactory centres—spatial segregation of fruit and pheromone representation.
Cell 128,1187–1203.

Komiyama, T., Johnson, W.A., Luo, L., Jefferis, G.S.X.E. (2003).
From lineage to wiring specificity—POU domain transcription factors control precise connections of Drosophila olfactory projection neurons.
Cell 112,157–167.

Jefferis, G.S.X.E., Marin, E.C., Stocker, R.F., Luo, L (2001).
Target neuron prespecification in the olfactory map of Drosophila.
Nature 414, 204–208.

 

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Group Members

  • Sebastian Cachero
  • Aaron Ostrovsky
  • Johannes Kohl
  • Shahar Frechter
  • Julian Ng
  • Michael-John Dolan
Our broad goal is to understand how smell turns into behaviour in the fruit fly brain. We currently use a combination of genetic labelling and manipulation, targeted in vivo whole cell patch clamp recording and highresolution computational neuroanatomy to study olfactory circuits.

We are particularly interested in how odour information is processed by the higher olfactory centres that mediate innate and learned behaviour.

One special interest is understanding how third order olfactory neurons of one of these higher centres, the lateral horn, integrate information from specific olfactory channels.

This process of selective integration is fundamental to perception and likely to underlie innate behavioural responses to general odours and sex pheromones.

Last Updated on Friday, 27 January 2012 12:31