Olfactory perception in the fruit fly
Our broad goal is to understand how smell turns into behaviour in the fruit fly brain. We currently use a combination of genetic labelling and manipulation, targeted in vivo whole cell patch clamp recording and high-resolution computational neuroanatomy to study olfactory circuits.
We are particularly interested in how odour information is processed by the higher olfactory centres that mediate innate and learned behaviour.
One special interest is understanding how third order olfactory neurons of one of these higher centres, the lateral horn, integrate information from specific olfactory channels.
This process of selective integration is fundamental to perception and likely to underlie innate behavioural responses to general odours and sex pheromones.
- Kohl, J., Ostrovsky, A.D., Frechter, S. and Jefferis, G.S. (2013)
A Bidirectional Circuit Switch Reroutes Pheromone Signals in Male and Female Brains
Cell 155-7: 1610-1623
- Grosjean, Y., Rytz, R., Farine, J.P., Abuin, L., Cortot, J., Jefferis, G.S. and Benton, R. (2011)
An olfactory receptor for food-derived odours promotes male courtship in Drosophila.
Nature 478: 236-240.
- Cachero, S., Ostrovsky, A., Yu, J., Dickson, B., Jefferis, G.S. (2010)
Sexual dimorphism in the fly brain.
Current Biology Vol 20 18: 1589-1601.
- Jefferis, G.S., Potter, C.J., Chan, A.M., Marin, E.C., Rohlfing, T., Maurer Jr., C.R. and Luo, L. (2007)
Comprehensive maps of Drosophila higher olfactory centres—spatial segregation of fruit and pheromone representation.
Cell 128: 1187–1203.
- Sebastian Cachero
- Shahar Frechter
- Ben Sutcliffe
- Paavo Huoviala
- Danielle Mersch
- Erika Dona
- Alexander Bates
- Dana Galili
- Philipp Schlegel