Martens, S., Kozlov, M.M. & McMahon, H.T. (2007)
How synaptotagmin promotes membrane fusion.
Science 316, 1205-1208
Daumke, O., Lundmark, R., Vallis, Y., Martens, S.,
Butler, P.J.G. & McMahon, H.T. (2007)
Architectural and mechanistic insights into an EHD
ATPase involved in membrane remodelling.
Nature 449, 923-927.
Henne, W.M., Boucrot, E., Meinecke, M., Evergren, E., Vallis, Y., Mittal R. and McMahon, H.T. (2010)
FCHo Proteins are Nucleators of Clathrin-Mediated Endocytosis.
Science 328, 1281-1284.
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Group Members
- Yvonne Vallis
- Rohit Mittal
- Wai-Ching Hon
- Emma Evergren
- Nicole Liska
- Emmanuel Boucrot
- Safa Lucken-Ardjomande
- Alexandra Fragniere
- Vladan Martinovic
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Cell shape is adapted to function. Organelle shape and local membrane architectures are likewise optimised for the processes that take place on and within these microenvironments. We focus on the dynamic regulation of membrane shape, which can occur by the interplay between the transient and regulated insertion of membrane bending motifs and the detection and stabilisation of membrane shape.
This approach has allowed us not only to describe the biophysics of membrane shape changes but also to take a fresh look at physiological processes like exocytosis and endocytosis. In doing so we have noted that proteins with amphipathic helices or hydrophobic membrane-inserting loops are likely to effect or respond to curvature and that the membrane interaction surfaces of proteins can sense shape (like proteins of the BAR superfamily).
Endophilinstabilised membrane curvature
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Left : Characterisation
of a tubular
endocytic
pathway
Right : EHD2, a dynamin superfamily member which remodels membranes
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This molecular view has allowed us to ascribe novel cell-biological functions to proteins (e.g. the mechanistic affect of synaptotagmin in membrane fusion) and to give a more insightful view of how these processes work. Thus we can now go from the biophysics of a molecule, to better understanding of known pathways and to the molecular characterisation of novel cellular trafficking pathways both of endocytosis and exocytosis.
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Group Leaders 
