Contact me by email:
This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Group Members
Donna Mallery
Marina Vaysburd
Amanda Price
Katsiaryna Bichel
Susanna Bidgood
William McEwan
Ruth Watkinson
Felix Hauler
Jerry Tam
X-ray structure of the TRIM21 PRYSPRY:Fc complex
Intracellular antibody neutralization of adenovirus infection
Despite extracellular adaptive and innate immunity, viral and bacterial pathogens are still able to infect cells. Because of this there must be a way to neutralise pathogens once they are inside the cell. Historically, infected cells have been seen as largely helpless and only able to signal for help. However, there is increasing evidence that cells have their own mechanisms for directly restricting pathogen replication. It is this process of intracellular immunity that my lab is interested in.
Intracellular antibody immmunity
In order to study intracellular immunity, we are combining cellular pathogen infection experiments with structural and biophysical approaches. Using these techniques we are attempting to address how the host targets fast evolving pathogens and the different mechanisms that are employed to neutralise them.
Active-site remodelling in anti-HIV TRIMCyp
Antibody-coated adenovirus is targeted by TRIM21 inside cells
Group Leaders 
