Felix_Randow

Felix Randow

Cell-autonomous and innate immunity
randow@mrc-lmb.cam.ac.uk
Personal group site

We are interested in cell autonomous innate immunity, i.e. in the ability of individual cells to defend themselves against infection.

salmonella autophagy pathways
Targeting of anti-bacterial autophagy to a cytosol-invading bacterium through galectin‑8‑mediated glycan detection on a damaged endomembrane and recruitment of the cargo receptor NDP52.

Cytosolic defence against bacterial invasion

The mammalian cytosol is rich in nutrients but can be colonized by specialized bacteria only. We therefore wish to understand i) how cells succeed in defending their cytosol against most invasion attempts and ii) how professional cytosol dwelling bacteria outwit cellular defences. We are particularly interested in danger receptors that detect breaches in cellular integrity, and in the ubiquitin system that marks invading bacteria as cargo for autophagy receptors.

Regulation of NF-κB and IRF signalling

The defence against pathogens requires profound changes in gene expression that are coordinated by latent transcription factors of the NF-kB and IRF families. We aim to understand how infection activates NF-κB and IRF signalling.

Somatic cell genetics

The genetic analysis of somatic cell lines holds significant potential for our understanding of signal transduction and other cell autonomous traits. We use haploid cells, CRISPR technology, and chemical mutagenesis to isolate genes governing the interaction between pathogens and host cells.

Selected Papers

Group Members

  • Keith Boyle
  • Michal Wandel
  • Alexander Von der Malsburg
  • Jessica Noad
  • Cara Ellison
  • Frances Acklam
  • Claudio Pathe
  • Emma Werner