Chemical origins of molecular biology
We are interested in uncovering prebiotically plausible syntheses of the informational, catalytic and compartment–forming molecules necessary for the emergence of life. We have previously demonstrated the constitutional self-assembly of pyrimidine ribonucleotides from mixtures of simple building blocks, and we are now exploring similar 'systems chemistry' approaches to the purine ribonucleotides, and ways of assembling RNA from these ribonucleotides with regiocontrol of the internucleotide phosphodiester linkage. We are also interested in the chemical origins of genetically encoded translation, and the abiogenesis of lipids.
- Powner, M.W. and Sutherland, J.D. (2010)
Phosphate-mediated interconversion of ribo- and arabino-configured prebiotic nucleotide intermediates.
Angew Chem Int Ed 49: 4641-4643.
- Powner, M.W., Sutherland, J.D. and Szostak, J.W. (2010)
Chemoselective multicomponent one-pot assembly of purine precursors in water.
J Am Chem Soc 24: 16677-16688.
- Powner, M.W., Gerland, B. and Sutherland, J.D. (2009)
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions.
Nature 459: 239-242.
- Christopher Chan
- Dougal Ritson
- Jianfeng Xu
- Frank Bowler
- Bhavesh Patel
- Claudia Percivalle
- Anders Albertsen