Cellular and molecular mechanisms of behaviour
We are investigating these questions using the nematode Caenorhabditis elegans, which has an anatomically simple and well-defined nervous system and is tractable to molecular and classical genetic analysis.
Using recently developed methods for in vivo optical neuroimaging, we are investigating how the activities of individual neurons correlate with behaviour, and how genes with interesting behavioural phenotypes affect the activities of individual neurons in defined neural circuits. In particular, we are interested in circuits mediating avoidance responses to touch and noxious chemical stimuli.
We are also investigating how behavioural plasticity caused by learning or chronic exposure to drugs is mediated at the level of individual cells.
Finally, we are interested in developing machine vision approaches for the rapid and consistent quantitation of behavioural phenotypes, which we plan to use for genome-wide phenotypic studies of C. elegans behavioural patterns.
- Yan, G., Vértes, P.E., Towlson, E.K., Chew, Y.L., Walker, D.S., Schafer, W.R. and Barabási, A-L. (2017)
Network control principles predict neuron function in the Caenorhabditis elegans connectome
- Chew, Y.L., Walker, D.S., Towlson, E.K., Vértes, P.E., Yan, G., Barabási, A-L. and Schafer, W.R. (2017)
Recordings of Caenorhabditis elegans locomotor behaviour following targeted ablation of single motor neurons
Sci Data 4: 170156
- Bentley, B., Branicky, R.S., Barnes, C.L., Chew, Y.L., Yemini, E., Bullmore, E.T., Vértes, P.E. and Schafer, W.R. (2016)
The multilayer connectome of Caenorhabditis elegans
Plos Comput Biol 12(12): e1005283.
- Rabinowitch, I., Chatzigeorgiou, M., Zhao, B., Treinin, M. and Schafer, W.R. (2014)
Rewiring neural circuits by the insertion of ectopic electrical synapses in transgenic C. elegans
Nature Communications 5: 4442
- Chatzigeorgiou, M., Bang, S., Hwang, S.W. and Schafer, W.R. (2013)
tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans.
Nature 494: 95-99.
- Brown, A.E.X., Yemini, E.I., Grundy, L., Jucikas, T. and Schafer, W.R. (2013)
A dictionary of behavioral motifs reveals genes affecting C. elegans locomotion.
Proc Natl Acad Sci USA 110: 791-796.
- Chatzigeorgiou, M. and Schafer, W.R. (2011)
Lateral facilitation between primary mechanosensory neurons controls nose touch perception in C. elegans.
Neuron 70: 299-309.
- Chatzigeorgiou, M., Yoo, S., Watson, J.D., Lee, W.H., Spencer, C., Kindt, K.S., Hwang, S.W., Miller, D.M., Treinin, M., Driscoll, M. and Schafer, W.R. (2010)
Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors.
Nature Neuosci 13: 861-868.
- Suzuki, H., Thiele, T., Faumont, S., Ezcurra, M., Lockery, S. and Schafer, W.R. (2008)
Functional asymmetry in C. elegans salt taste neurons and its computational role in chemotaxis behaviour.
Nature 454: 114-117.
- Yee Lian Chew
- Laura Grundy
- Iris Hardege
- Eva Kaulich
- Akihiro Mori
- Julia Morud Lekholm
- Alina Ritz
- Yiquan Tang
- Denise Walker