Systematic genetic code reprogramming
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We are developing approaches for systematically reprogramming the genetic code of cells and organisms. These approaches involve engineering the translational machinery of cells and the genome with the goal of rewriting the genetic code for unnatural polymer synthesis.
Wang, K., Fredens, J., Brunner, S. F., Kim, S. H., Chia, T. and Chin, J. W.
Defining synonymous codon compression schemes by genome recoding.
Nature 2016 in press
Neumann, H., Wang, K., Davis, L., Garcia-Alai, M. and Chin, J.W. (2010)
Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome.