A variety of projects can be considered, building on our recent advances (see references). Students interested in joining the group are encouraged to suggest an original project, inspired by or building on prior work from the group, or one that explores novel ideas in related topics.

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References

Establishing a synthetic orthogonal replication system enables accelerated evolution in E. coli.
R. Tian, F. B. H. Rehm, D. Czernecki, Y. Gu, J. F. Zurcher, K. C. Liu, J. W. Chin.
Science. 2024. 383: 421-426.

Adding α,α-disubstituted & β-linked monomers to the genetic code of an organism
D. L. Dunkelmann, C. Piedrafita, A. Dickson, K. C. Liu, T. S. Elliott, M. Fiedler, D. Bellini, A. Zhou, D. Cervettini, J. W. Chin.
Nature. 2024. 625: 603-610.

Continuous synthesis of E. coli genome sections and megabase-scale human DNA assembly.
J. F. Zürcher, A. A. Kleefeldt, L. F. H. Funke, J. Birnbaum, J. Fredens, S. Grazioli, K. C. Liu, M. Spinck, G. Petris, P. Murat, F. B. H. Rehm, J. E. Sale, J. W. Chin,
Nature 2023. 619: 555-562.