Besides the joint project on experimental cryo-EM of amyloid filaments, as advertised with Michel Goedert, the Scheres group is also interested to receive applications from PhD students with an interest in the development of computational methods for Structural Biology. Possible projects are in the development of new image processing approaches for cryo-electron tomography (cryo-ET) to better visualise macromolecular complexes in their cellular environment; and in the development of new approaches for protein design.

References

A. Burt, B. Toader, R. Warshmanage, A. von Kugelgen, E. Pyle, J. Zivanov, D. Kimanius, T.A.M. Bharat & S.H.W. Scheres (2024)
An image processing pipeline for electron cryo-tomography in RELION-5
FEBS Open Bio https://doi.org/10.1002/2211-5463.13873

D. Kimanius, K. Jamali, M.E. Wilkinson, S. Lovestam, V. Velazhahan, T. Nakane & S.H.W. Scheres (2024)
Data-driven regularisation lowers the size barrier of cryo-EM structure determination
Nature Methods 21, 1216-1221.

K. Jamali, L. Kall, R. Zhang, A. Brown, D. Kimanius & S.H.W. Scheres (2024)
Automated model building and protein identification in cryo-EM maps
Nature 628, 450–457